LymphedemaV1, Main, Exploration, bibRecord, 002979

Interleukin 1 (IL-1)- and IL-23-Mediated Expansion of Filarial Antigen-Specific Th17 and Th22 Cells in Filarial Lymphedema

Identifieur interne : 002979 ( Main/Exploration ); précédent : 002978; suivant : 002980

Interleukin 1 (IL-1)- and IL-23-Mediated Expansion of Filarial Antigen-Specific Th17 and Th22 Cells in Filarial Lymphedema

Auteurs : R. Anuradha [Inde] ; P. Jovvian George [Inde] ; V. Chandrasekaran [Inde] ; P. Paul Kumaran [Inde] ; Thomas B. Nutman [États-Unis] ; Subash Babu [Inde, États-Unis]

Source :

Clinical and Vaccine Immunology : CVI [ 1556-6811 ] ; 2014.

RBID : PMC:4097448

Descripteurs français

KwdFr :
- Animaux, Brugia malayi (immunologie), Cellules Th17 (immunologie), Facteur de croissance transformant bêta (immunologie), Filariose lymphatique (anatomopathologie), Filariose lymphatique (immunologie), Humains, Interleukine-1 (immunologie), Interleukine-23 (immunologie), Sous-populations de lymphocytes T (immunologie), Wuchereria bancrofti (immunologie).
MESH :
- anatomopathologie : Filariose lymphatique.
- immunologie : Brugia malayi, Cellules Th17, Facteur de croissance transformant bêta, Filariose lymphatique, Interleukine-1, Interleukine-23, Sous-populations de lymphocytes T, Wuchereria bancrofti.
- Animaux, Humains.

English descriptors

KwdEn :
- Animals, Brugia malayi (immunology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (pathology), Humans, Interleukin-1 (immunology), Interleukin-23 (immunology), T-Lymphocyte Subsets (immunology), Th17 Cells (immunology), Transforming Growth Factor beta (immunology), Wuchereria bancrofti (immunology).
MESH :
- chemical , immunology : Interleukin-1, Interleukin-23, Transforming Growth Factor beta.
- immunology : Brugia malayi, Elephantiasis, Filarial, T-Lymphocyte Subsets, Th17 Cells, Wuchereria bancrofti.
- pathology : Elephantiasis, Filarial.
- Animals, Humans.

Abstract

Lymphatic filarial disease is known to be associated with elevated Th1 responses and normal or diminished Th2 responses to parasite-specific antigens. The roles of Th17 cells and the recently described Th22 cells have not been examined in detail in either filarial infection itself or in filarial disease (e.g., lymphedema and elephantiasis). To explore the roles of Th17 and Th22 cells and their subsets, we examined the frequencies of these cells in individuals with filarial lymphedema (chronic pathology [CP]), in clinically asymptomatic infected (INF) individuals, and in uninfected (UN) individuals ex vivo and in response to parasite and nonparasite antigens. Those with disease (CP) had significantly expanded frequencies of Th17 and Th22 cells, compared with either INF or UN individuals, at baseline (ex vivo) and in response to parasite antigens. This antigen-driven expansion of Th17 and Th22 cells was dependent on interleukin 1 (IL-1), IL-23, and, to lesser extent, transforming growth factor β (TGF-β), as blockade of any of these cytokines resulted in significantly diminished frequencies of Th17 and Th22 cells. Our findings, therefore, suggest that filarial parasite-driven expansion of Th17 and Th22 cells is associated with the pathogenesis of filarial infections and disease.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097448

DOI: 10.1128/CVI.00257-14
PubMed: 24807054
PubMed Central: 4097448

Affiliations:

Le document en format XML

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<term>Humans</term>
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<front><div type="abstract" xml:lang="en"><p>Lymphatic filarial disease is known to be associated with elevated Th1 responses and normal or diminished Th2 responses to parasite-specific antigens. The roles of Th17 cells and the recently described Th22 cells have not been examined in detail in either filarial infection itself or in filarial disease (e.g., lymphedema and elephantiasis). To explore the roles of Th17 and Th22 cells and their subsets, we examined the frequencies of these cells in individuals with filarial lymphedema (chronic pathology [CP]), in clinically asymptomatic infected (INF) individuals, and in uninfected (UN) individuals <italic>ex vivo</italic>
 and in response to parasite and nonparasite antigens. Those with disease (CP) had significantly expanded frequencies of Th17 and Th22 cells, compared with either INF or UN individuals, at baseline (<italic>ex vivo</italic>
) and in response to parasite antigens. This antigen-driven expansion of Th17 and Th22 cells was dependent on interleukin 1 (IL-1), IL-23, and, to lesser extent, transforming growth factor β (TGF-β), as blockade of any of these cytokines resulted in significantly diminished frequencies of Th17 and Th22 cells. Our findings, therefore, suggest that filarial parasite-driven expansion of Th17 and Th22 cells is associated with the pathogenesis of filarial infections and disease.</p>
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Serveur d'exploration sur le lymphœdème

Interleukin 1 (IL-1)- and IL-23-Mediated Expansion of Filarial Antigen-Specific Th17 and Th22 Cells in Filarial Lymphedema

Interleukin 1 (IL-1)- and IL-23-Mediated Expansion of Filarial Antigen-Specific Th17 and Th22 Cells in Filarial Lymphedema

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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